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As the patient ages, the number of cells in the NP and AF decreases, the ability of the NP to retain water is reduced, and the AF gradually loses moisture and displays fibrosis. The major cause of long-term chronic LBP is degeneration of the IVDs, which, as indicated above, typically worsens with age. Studies have indicated that evidence of IDD can be identified by magnetic resonance imaging (MRI) in approximately 30% of asymptomatic adult test subjects over 30 years old, while similar changes can be identified in almost all individuals over 60 years old. Its diagnosis is based on the presence of chronic LBP (sometimes accompanied by radicular pain) and positive provocative discography. This is because of the resulting impaired ability of the spine to distribute pressure, which again is caused by dehydration and deterioration of the IVDs. The causes of chronic LBP can be extremely diverse, but lumbar IDD is one major cause of chronic LBP.
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Once IDD occurs, irreversible deterioration continues. Relatedly, IDD usually occurs in adult individuals, and as IDD progresses, the load surrounding AF tissues increases, causing the IVDs to collapse, which in turn generates direct friction in the vertebral body and induces the growth of bone spurs and/or LBP. Although the water content of NP tissues in children is typically greater than 80%, it decreases with age, dropping as low as 70% in older individuals, and this loss of water content is a major cause of IDD. NP tissues retain high water content and provide a crucial buffer function of maintaining IVD height and spinal joint mobility. Intervertebral disc (IVD) tissues are located between IVD bodies and are composed of annulus fibrosus (AF) and nucleus pulposus (NP) tissues.
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Low back pain (LBP) is often induced by intervertebral disc degeneration (IDD), which is a major disease of aging. Therefore, Elgucare can potentially be used as a clinical supplement. Elgucare can increase the water retention and height of IVDs and reduce LBP, thereby enhancing quality of life. However, the BMD results showed no improvements. The results of another questionnaire indicated that Elgucare slowed the LBP-induced deterioration of patients’ quality of life, while objective assessment indices obtained through X-ray and magnetic resonance imaging showed that the height and water retention of their IVDs were increased. Elgucare reduced the patients’ mean VAS pain score by 2.25 points and improved their mean LBP-hampered mobility as assessed by the Roland-Morris Questionnaire by 5.17 points. These parameters were evaluated before and after the administration of Elgucare or a placebo, one of which was taken by each participant for a 12-month period. The assessment was done through the visual analogue scale (VAS) and effects on lumbar IVD thickness, water content, and bone mineral density (BMD). The study assessed patient subjective quality of life, functional limitations caused by LBP, and variations in pain.
Spss 23 trial trial#
This clinical trial investigated the use of Elgucare, a Chinese herbal formula, as a food supplement to reduce the pain of patients with LBP induced by degeneration of the lumbar IVDs. However, most cases are induced by degeneration of the lumbar intervertebral discs (IVDs), and the aching caused by local compression of the affected region has considerable impacts on quality of life.
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Chronic low back pain (LBP) has a wide range of causes.